Capsaicin impact on the gastrointestinal tract Health Articles | December 6 Cheap NFL Jerseys , 2012 There is a big controversy on the reports about capsaicin on gastrointestinal cancer, and some studies by?pharmaceutical raw materials suppliers?suggest that capsaicin can inhibit tumor cell, also some researches found that the capsaicin can promote tumor cell proliferation, there are some reports show that capsaicin has no effect on tumor cells.?
Researchers doing more researches about capsaicin on gastricmotility, most of them reported that small doses the capsaicin can promotegastric motility, large dose of capsaicin on gastric motility have inhibitionrole.
Effects of capsaicin on gastric mucosa Cheap Jerseys China , inrecent years, there are many international studies have shown that the rightamount of capsaicin on gastric mucosal have protective effect. The probability ofChinese people in Singaporesuffering from gastric ulcer is three times than Malaysians and Indians, andmay be related with Malaysians and Indians eat more chili. Capsaicin, capsaicin-sensitiveafferent nerves and capsaicin receptor and gastric mucosal injury and repair areclosely related. Capsaicin-sensitive neuron cell body is able to synthesizetachykinins of substance P (substance P, SP), neurokinin peptide A (neurokininA) to the axon terminals transport of these peptides. Stomach CSSN through therelease of calcitonin gene peptide (calcitonin gen related peptide Cheap Jerseys , CGRP)increased gastric mucosal blood flow, and a series of reactions mediated byCGRP, thereby increasing the gastric mucosal resistance to maintain gastricmucosal integrity. Acid-induced gastric ulcer, congestive reaction capsaicinsensitive afferent neurons by regulating CGRP release to promote the role ofthe acid treatment of the gastric mucosa, thereby treating gastric ulcer.
The functional activity of the CSSN gastricacid and gastric mucosal blood flow is more important to the regulation ofgastric mucosal blood flow. Intragastric perfusion with peptone, causing anincrease in gastric acid secretion and gastric mucosal blood flow; terms of thecapsaicin afferent denervation weakened the intragastric peptone caused anincrease in gastric acid secretion effect Wholesale NFL Jerseys Online , increase in gastric mucosal bloodflow effects almost completely disappeared. The surface mucosal growth factorby capsaicin-sensitive afferent nerve play the congestive role and protectingthe stomach and gastric mucosa. Gastric mucosa dominated by the vagus nerve andspinal afferent, when gastric mucosa stimulated by harmful chemicals, these afferentnerve though increased gastric mucosal blood flow to protect and repair thegastric mucosa.
Capsaicin have certain effects on gastricacid secretion, the majority of studies by capsaicinsupplier have shown that small doses can inhibit gastric acid secretion,large doses may promote gastric acid secretion, also some reports chain that acertain dose of capsaicin has no effect on gastric acid secretion. Capsaicinmay through directly stimulate the central Wholesale NFL Jerseys Cheap , peripheral capsaicin-sensitivesensory nerve and Pik cells capsaicin receptor, causing calcitonin gene-relatedpeptide, P substance, neurokinin A, vasoactive intestinal peptideneurotransmitter release to participate in the regulation of gastric acid secretion.
Capsaicin on gastric cancer cells havesignificant growth inhibition and induction of apoptosis in a dose-andtime-dependent manner, mainly through the regulation of Bax Wholesale NFL Jerseys Free Shipping , Bcl-2 and C-mycprotein expression to achieve. Capsaicin dose relationship manner to reduce thecell viability of the human colon, capsaicin also cause the fragmentation ofthe changes in cell morphology and DNA, DNA content decreases,phosphatidylserine shift, wherein phosphatidylserine of the shift marks cellsapoptosis. The mechanism of capsaicin-induced apoptosis may be semi-caspase 3(a major apoptosis-inducing enzyme) activity is enhanced. At present, theinternational community about the effects of capsaicin on gastrointestinalhealth research relatively large Wholesale NFL Jerseys From China , but its mechanism of action is relativelyweak, especially affect the outcome of colorectal cancer and its mechanismshould be further explore.
Source:http:www.cospcn Article Tags: Gastric Mucosal Blood, Mucosal Blood Flow, Gastric Acid Secretion, Gastric Motility, Gastric Mucosa Wholesale NFL Jerseys China , Gastric Mucosal, Gastric Ulcer, Mucosal Blood, Blood Flow, Gastric Acid, Acid Secretion Try These Herbal Remedies for High Blood Pressure for Healthier Life Health Articles | February 13 Wholesale NFL Jerseys , 2011 Blood pressure is one of the common ailments of today''s fast-paced and tension-ridden lifestyle world. Try some effective herbal remedies for high blood pressure. Blood pressure or hypertension is one of the common ailments of today''s fast-paced and tension-ridden lifestyle world. It is more of a lifestyle disease and if anyone wants to have to complete cure from this serious ailment. Change to lifestyle is very essential apart from looking at some remedies which are safe, effective and can be used on long term basis.?
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